What Is TB-500?
TB-500 is a synthetic version of Thymosin Beta-4, a 43-amino-acid peptide first isolated from the thymus gland. It plays a central role in actin polymerization.
Mechanism of Action
TB-500 binds to G-actin monomers, regulating actin filament assembly critical for cell motility. The active region is LKKTETQ.
Investigated Applications
- Cell migration in wound scratch assays
- Actin polymerization via G-actin sequestration
- Inflammatory modulation via NF-kB pathway
- Angiogenesis via VEGF upregulation
Not FDA-approved. Banned by WADA. Preclinical data only.
Cited Sources
- According to Goldstein, A.L. et al. (2012). "Thymosin beta4: multi-functional regenerative peptide." Expert Opin Biol Ther. [PubMed]